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The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. The source of the information is mentioned in the introductory sentence of the hazard statements.

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Models that do not have both of these features require that the answers that are being sought have to be specified exogenously. An iterative procedure can be used to reconcile unrealistic results but only with difficulty Science.

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  • The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union.

Extraskeletal findings such as cardiac and pulmonary complications are generally considered to be significant secondary features. Aga2, a murine model for human OI, was systemically analyzed in the German Mouse Clinic by means of in vivo and in vitro examinations of the cardiopulmonary system, to identify novel mechanisms accounting for perinatal lethality.

In addition, dysregulated gene expression of Nppa, different types of collagen and Agt in heart and lung tissue support a bone-independent vicious cycle of heart dysfunction, including hypertrophy, loss of myocardial matrix integrity, pulmonary hypertension, pneumonia and hypoxia leading to death in Aga2.

These murine findings are corroborated by a pediatric OI cohort study, displaying significant progressive decline in pulmonary function and restrictive pulmonary disease independent of scoliosis.

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More help available here. Harmonised classification and labelling CLH Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. If the substance is covered by more than one CLH entry e.

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It is possible that a harmonisation is introduced through an amendment to the CLP Regulation. More info on CLH can be found here. This information has not been reviewed or verified by ECHA, and may change without prior notice.

Account Options

These notifications can be provided by manufacturers, importers and downstream users. There is no harmonised classification and there are no notified hazards by manufacturers, importers or downstream users for this substance.

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Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. The use information is displayed per substance life cycle stage consumer use, in articles, by professional workers widespread usesin formulation or re-packing, at industrial sites or in manufacturing.

Nitrilotriacetic acid

The information is aggregated from the data coming from REACH substance registrations provided by industry. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.

The examples provided are generic examples and may not apply to the specific substance you are viewing. A substance may have its use restricted to certain articles or products and therefore not all the examples may apply to the specific substance.

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Furthermore, some substances can be found in an article, but with unlikely exposure e. The described Product category i.

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More help is available here. This substance is used by consumers, in articles, by professional workers widespread usesin formulation or re-packing, at industrial sites and in manufacturing. Other release to the environment of this substance is likely to occur from: outdoor use, indoor use e.

Key datasets

Article service life Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate e.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

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Widespread uses by professional workers This substance is used in the following products: pH regulators and water treatment products and laboratory chemicals. This substance is used in the following areas: health services and scientific research and development. Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles, as processing aid and of substances in closed systems with minimal release.

Other release to the environment of this substance is likely to occur from: indoor use e.